Clinical trial of norfloxacin in urinary tract infection.

نویسندگان

  • M L Dawani
  • M A Sheikh
  • S A Naqvi
چکیده

Forty six patients, with acute pyelonephritis or cystitis and a significant colony count were treated with Norfloxacin 400mg, 12 hourly for 7 days. The prevalent organisms were E.Coli (83%) and Ps pyocyanea (11%). Cure rate after one week’s treatment was 98%. Nine patients (20%) had recurrence of infection one to six weeks after stopping the drug. Tolerance to the drug was excellent. Norfloxacin is safe and effective in uncomplicated as weH complicated urinary tract infections (JPMA 37: 152, 1987).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of Quinolone Resistance in Escherichia coli Isolates Recovered from Urine and Feces of Patients with Acute or Recurrent Urinary Tract Infection

Introduction: Antibiotic resistance, especially in Gram-negative uropathogens such as Escherichia coli, is the main barrier to treat urinary tract infection (UTI). In recent years, the dramatically increased resistance of E. coli to quinolones, a group of widely used antibiotics, has become a significant concern. Methods: In this descriptive cross-sectional study, we collected 261 E. coli isola...

متن کامل

Detection of Efflux Pumps Genes in Fluoroquinolones Resistant and Sensitive strains of Escherichia coli isolated from Patients with Urinary Tract Infection in Qom

Abstract Background and Objectives: Efflux pumps are one of the main mechanisms for antibiotic resistance in Escherichia coli strains. The aim of this study was to investigate the relationship between 5 different efflux pump genes; acrA, acrB, emrA, emrB and mdtk and fluoroquinolone resistance in E.coli Isolated from patients with urinary tract infections in Qom. Methods: In this descriptive cr...

متن کامل

Norfloxacin versus trimethoprim-sulfamethoxazole in the therapy of uncomplicated, community-acquired urinary tract infections.

In a prospective, randomized trial, norfloxacin (400 mg perorally, twice a day) was compared with trimethoprim-sulfamethoxazole (160-800 mg perorally, twice a day) in 45 patients with uncomplicated urinary tract infections. Escherichia coli was the most common isolate. Infections due to Enterobacter spp., Proteus mirabilis, Pseudomonas spp., and Staphylococcus spp. were also treated. Norfloxaci...

متن کامل

Evaluation of the Effect of Single Dose of Prophylactic Ciprofloxacin Before Simple Cystourethroscopy on the Incidence of Urinary Tract Infection: A Randomized Clinical Trial

Introduction: The assumed necessity of antimicrobial prophylaxis prior to simple cystoscopy is controversial. The aim of this study is to determine whether antibiotic prophylaxis is required before this outpatient procedure. Methods: A total of 162 patients with mean age of 51 years old (range: 12–82 years old) were recruited. They were randomized into two groups: First group did not receive a...

متن کامل

Trimethoprim-sulfamethoxazole for treatment of urinary tract infections.

Three hundred seventy patients with upper or lower urinary tract infections were entered into a multicenter, open comparative study. A total of 190 patients were treated with norfloxacin, and 180 patients were treated with trimethoprim-sulfamethoxazole. The percentage of strains susceptible to norfloxacin (99%) was significantly greater (P less than 0.001) than the percentage of strains suscept...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • JPMA. The Journal of the Pakistan Medical Association

دوره 37 6  شماره 

صفحات  -

تاریخ انتشار 1987